A direct successor of the Columbia 300, Columbia 350 included a glass cockpit, has fully electric buses (no vacuum pumps) and a number of other "creature comforts" initially developed for the Columbia 400 (like air conditioning). It is currently marketed as Cessna Corvalis and is still in production.

The 350 has the same MTOW (3400 lbs) and MLW (3230 lbs) as the 300 and uses the same TCM IO-550-N engine producing 310 HP.